I'd got some unwanted spam message and wondered if it was possible to stop accidental clicking on any URLs that are displayed in those cases.
Turns out you can easily.
Go to the Edit menu > Preferences > Advanced > Config Editor. Skip past the warning about changing advanced settings if it's displayed (you must have already disabled it previously, if you don't see this).
Search for network.protocol-handler.external-default, right click the option of that name that appears under Preference Name and select Toggle to change it from the default (true) to false.
Now, if you try to click on a URL now that's displayed in an email, nothing will happen; your web browser won't open. However, you can always copy the URL and paste into a browser yourself.